A 24-hour strike on Northern Rail services is expected to disrupt public transport arrangements across Greater Manchester.
Members of the Rail, Maritime and Transport (RMT) union staged a walk out on the morning of Friday 28 April.
RTM said it was “angry and frustrated” over changes due to come into rail services in 2020.
Northern Rail are hoping to still operate more than 40% of services but have warned commuters that routes will be “extremely busy”.
Mick Cash, RMT general secretary, said: “The responsibility for the inevitable disruption lies wholly with the company.”
Cash also said that his members remained “united and determined”.
Union members believe Northern Rail are trying to “bulldoze through” plans for driver-only-operated trains.
Northern Rail said it was still prepared to talk with RMT – expressing disappointment that the strike was going ahead.
Demonstrations were also seen outside Parliament on Wednesday 26 April marking the one-year anniversary of RMT’s dispute with Southern Rail.
This strike action against Northern Rail coincides with the first day of the Tour de Yorkshire cycle race.
The race starts in Bridlington, East Yorkshire and finishes in Scarborough, North Yorkshire on the day of the strike.
Both Transport for Greater Manchester and Transport for West Yorkshire have warned of significant disruption.
Numbers travelling will also likely increase as Friday marks the start of the May Bank Holiday weekend.
Transport for Greater Manchester, which is helping co-ordinate the region’s response, have urged people to plan ahead.
TfGM’s John Fryer said: “We are taking action to minimise the disruption but we know there will still be problems.
“Commuters can play their part to minimise these.
“Our advice is simple: plan ahead, be prepared, and think about all your travel choices.”
TfGM have also added extra capacity and additional staff to the Metrolink network in attempts to cope with the strike.
A list of temporary replacement bus services can be found on the Northern Rail website.