Thousands of demonstrators took to the streets of the capital Pretoria to protest against President Jacob Zuma.
The protestors gathered near Union buildings in the city demanding African National Congress party (ANC) leader Zuma step down.
The march to Union Buildings, the official seat of government in South Africa, was organised by opposition parties.
Leftist Economic Freedom Fighters (EFF) party as well as the Democratic Alliance (DA) and smaller opposition parties organised the march.
This follows nationwide protest against the president last week.
The President’s recent dismissal cabinet member and finance minister, Pravin Gordhan has stoked anger with the public.
Bantu Holomisa, the United Democratic Movement (UDM) leader said to reporters: “We now announce to all South Africans to Africa and the rest of the world that we have declared 12 April a national day of action.”
Mkhuleko Hlengwa from IFP said: “Stand on the side of the people on the side of democracy and for them to protect us.
“Because we know that we are dealing with a character in the president who is not going to go down without a price.”
Zuma turned 75 on 12 April, the day of the protest, and is due to step down as the head of the ANC in December.
The President has survived numerous of corruption scandals, but South Africa are now facing record unemployment and a stagnating economy.